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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

MAP3K5 bound to TXN inhibits MAP3K5. 3 / 3

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"Oxidative stress causes the oxidation of TRX, which disrupts the ASK and TRX complex, thereby activating ASK1 to induce apoptosis [22]."

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"TXN binds to ASK1 and prevents ASK1 from full activation, thus downregulating the p38 pathway [XREF_BIBR]."

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"In the heart, reduced Trx1, Trx2 and/or glutaredoxin1 (Grx1) bind to and negatively regulate apoptosis signal regulating kinase 1 (ASK1), which inhibits ASK-1 from inducing apoptosis [XREF_BIBR - XREF_BIBR]."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

MAP3K5 bound to TXN inhibits MAP3K5. 3 / 3

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