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Statements

TNFAIP3 inhibits IKK_complex. 33 / 33
| 7 1 25
eidos
"TNF-induced expression of IkappaB attenuates NFkappaB , whereas A20 inhibits IKK and RIPK3 ."
33314666
sparser
"These results provide direct evidence that A20 inhibits IKK by preventing the phosphorylation of IKK by TAK1."
22099304
sparser
"It has been found that A20 inhibits the IKK complex by non-catalytic functions, mediated by recruitment of A20 to the C-terminal domain of IKKα [31,32] ."
28629782
sparser
"The model simulations ( xref ) confirmed the experimental findings that RC3H1 reduces A20 mRNA and subsequently A20 protein expression, and, due to the attenuated IKK inhibition by A20, leads to an increased IKK activity."
26170170
sparser
"We found evidence that A20 can inhibit IKK through a mechanism that cannot be accounted for by reducing the interaction of polyubiquitin chains with NEMO."
22099304
sparser
"A20 inhibition of IKK was dependent on A20 binding to NEMO which was induced by K63-linked polyubiquitin chains. xref The binding of A20 with NEMO occurred rapidly upon IL-1 stimulation (2–5 min) in HeLa cells. xref Therefore, the polyubiquitin chains that serve to activate IKK also serve a dual function in its negative regulation by the recruitment of A20 to NEMO."
22343828
eidos
"When NF-kappaB is activated , IkappaBs are released from the NF-kappaB DNA-binding domain , and A20 suppresses IKK activation ."
35098992
sparser
"The three upstream modules comprise the three distinct mechanisms of IKK inhibition by A20 that xref , xref , and xref have proposed."
32848849
sparser
"A20 Inhibits IKK Downstream of TRAF6 Through a Non-Catalytic Mechanism."
22099304
sparser
"The newly synthesized IkappaBalpha leads NF-kappaB out of the nucleus and sequesters it in the cytoplasm, while A20 inhibits IKK converting IKKa into the inactive form (IKKi), a form different from IKKn, no longer capable of phosphorylating IkappaBalpha."
15094015
sparser
"Our results suggest a mechanism by which A20 inhibits IKK without deubiquitination or impairment of ubiquitination enzymes."
22099304
sparser
"Our results therefore suggest a direct, non-catalytic mechanism of IKK inhibition by A20 and demonstrate that polyubiquitin chains can induce specific binding among proteins to which ubiquitin is not covalently attached."
22099304
sparser
"Recently, Skaug et al. reported a direct non-catalytic mechanism of IKK inhibition by A20 showing that overexpressed A20 impaired IKK activation without reducing RIP1 ubiquitination xref ."
24324544
sparser
"The newly synthesized I κ B α again inhibits NF- κ B, while A20 inhibits IKK by catalyzing its transformation into another inactive form in which it is no longer capable of phosphorylating I κ B α ."
20163703
sparser
"The rates for IKK inactivation by A20 significantly affect the termination of initial NF-κB activity as well as the second phase of activity."
21729324
sparser
"Recently, a study by the Chen group reported that A20 inhibits IKK by a noncatalytic mechanism."
22343828
sparser
"A second mechanism of IKK inhibition by A20 is mediated through its C-terminal zinc finger domains, which function as an E3 to promote K48-linked polyubiquitination of RIP1 and target it for degradation by the proteasome xref ."
19281271
sparser
"Our results suggest a non-catalytic mechanism of IKK inhibition by A20 and a means by which polyubiquitin chains can specify a signaling outcome."
22099304
reach
"In addition to TNFAIP3 modulating ubiquitin others have found that TNFAIP3 can also inhibit IKK complex activity through a mechanism that is independent of ubiquitin."
24678426
eidos
"IkappaBs ( NFKBIA [ IkappaBalpha ] , IKBKB [ IkappaBbeta ] , and IKBKE [ IkappaBepsilon ] ) and TNFAIP3 ( A20 ) are target genes of NF-kappaB ; when NF-kappaB is activated , IkappaBs are released from the DNA binding domain of NF-kappaB , and A20 suppresses IKK activation [ 144-146 ] ."
35098992
sparser
"Indeed, we present multiple lines of evidence that A20 inhibits IKK through a non-catalytic mechanism."
22099304
sparser
"However, direct evidence of IKK inhibition by A20 is lacking, and the inhibitory mechanism remains poorly understood."
22099304
sparser
"In this sense, our observation is similar to the previously reported noncatalytic mechanisms of IKK inhibition by A20 in the canonical pathway xref xref xref ."
24008839
eidos
"( a ) In the TNF-induced NF-kappaB pathway , A20 can impair IKK complex activation , thus opposing the activation of NF-kappaB ."
| PMC
eidos
"In short , all four models share a feedback inhibition of IKK activity by A20 but differ in the specifics of their A20 feedback implementations ."
32848849
eidos
"The three upstream modules comprise the three distinct mechanisms of IKK inhibition by A20 that Lipniacki et al. ( 2004 ) , Ashall et al. ( 2009 ) , and Murakawa et al. ( 2015 ) have proposed ."
32848849
sparser
"Our analysis suggests that direct A20 inactivation of IKK contributes more to later regulation than feedback inhibition of IKK activation, although more detailed models are likely to provide better insight into the complex regulatory role of A20."
21729324
eidos
"As a tumor suppressor , A20 directly inhibits IKK activation and HL cell survival via its C-terminal linear-ubiquitin binding ZF7 ."
33139544
sparser
"It gathers recovery (via k 3 ) and dynamical properties (via k 9 ), as well as the A20 dependent inactivation (via k 4 ) of the kinase IKK."
18854041
sparser
"As a tool to dissect the mechanism of IKK inhibition by A20, we stably overexpressed Flag-A20 in a HEK293 cell line that expresses IL-1R. In this cell line, IKK activation by TNFα was almost completely abolished, as evidenced by the lack of IκBα degradation and the failure of immunoprecipitated IKK complex to phosphorylate IκBα ( xref )."
22099304
sparser
"To further dissect the mechanism of IKK inhibition by A20, we tested whether purified A20 protein could inhibit IKK activation by TRAF6 in a cell-free system (S100) ( xref )."
22099304
sparser
"These include the deubiquitination enzymes CYLD and A20 that inhibit IKK, and the ubiquitin binding proteins NEMO and TAB2 which are the regulatory subunits of IKK and TAK1 kinase complexes, respectively."
22435549
sparser
""The newly synthesizedI κ B α again inhibitsNF- κ B, while A20 inhibits IKK by catalysing its transformation into another inactive form, in which it is no longer capable ofphosphorylating I κ B α .""
26045232