IndraLab

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EIF3F inhibits PHGDH. 1 / 1
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"In addition, eIF3f KD accelerates PHGDH protein turnover (Figure 2F), and leads to increased poly‐ubiquitination level of PHGDH (Figure 2G), while ectopic‐expression of eIF3f leads to increased steady‐state expression of PHGDH (Figure 2H) and reduced poly‐ubiquitination level of PHGDH in a dose‐dependent manner (Figure 2I)."