IndraLab

Statements

RPS6KB1 phosphorylates IRS1 on S636. 15 / 15
1 1 2 | 10 1
reach
"IRS-1 S302 and S632 (S307 and S636, respectively, in humans) are directly phosphorylated by S6K1 and mTORC1, respectively (Copps and White, 2012)."
25813876
reach
"In addition, when mTORC1 is activated, S6K1 could directly phosphorylate Insulin receptor substrate 1 (IRS1; S307 and S636 and S639) and promote its degradation, which subsequently blunts phosphoinositide 3-kinase (PI3K)-AKT activation and its downstream effects such as glucose uptake and glycogen accumulation."
33574765
reach
"Together, this may suggest that T-cad upregulation in SHR might be a characteristic feature of hypertensive and insulin resistant VSMC phenotype.Attenuation of insulin signaling is achieved through a [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24815187
biopax:phosphositeplus
No evidence text available
reach
"P70S6K phosphorylates IRS-1 on S312 and/or S636 and S639."
23006971
reach
"Moreover, mTORC1 and S6K1 activation directly mediated the hyperphosphorylation of IRS-1 Ser636 upon alpha-Syn overexpression, while PP2A activation reversed this process in SK-N-SH cells and transgen[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25813876
signor
"In this report, we identified insulin receptor substrate 1 (IRS-1), a critical mediator of the insulin/insulin-like growth factor 1 signaling, as a proteolytic target of the CUL7 E3 ligase in a manner that depends on mammalian target of rapamycin and the p70 S6 kinase activities.Elimination of phosphorylation at S307/S312/S527/S636/S639 renders V5-IRS-1 partially resistant to degradation by Fbw8"
18498745
reach
"These results indicate that alpha-Syn overexpression negatively regulates IRS-1 at least in part by stimulating IRS-1 Ser636 phosphorylation and tyrosine dephosphorylation by mTORC1 and S6K1."
25813876
reach
"When mTORC1 is activated, S6K1 could directly phosphorylate IRS1 (S307 and S636/S639) and promote its degradation, which subsequently blunts PI3K-AKT activation and its downstream effects such as glucose uptake, glycogen accumulation, etc. [2,3]."
30011848
reach
"Inhibition of mTOR and S6K1 by HM-chromanone significantly reduced IRS-1 Ser307 and IRS-1 Ser632 phosphorylation, leading to insulin resistance."
36337245
sparser
"IRS-1 S302 and S632 (S307 and S636, respectively, in humans) are directly phosphorylated by S6K1 and mTORC1, respectively ( Copps and White, 2012 )."
25813876
signor
"Nevertheless, s6k1-deficient mice remain sensitive to insulin owing to the apparent loss of a negative feedback loop from s6k1 to insulin receptor substrate 1 (irs1), which blunts s307 and s636/s639 phosphorylation; thus under conditions of nutrient satiation s6k1 negatively regulatesinsulin."
15306821
reach
"IRS-1 is phosphorylated at Ser636 by S6K1 which is activated by mTOR."
25472611
reach
"P70S6K can phosphorylate IRS-1 on S312 and/or S636 and S639."
24931005
biopax:netpath
No evidence text available
18952604