IndraLab

Statements

USP28 inhibits GSK3B. 2 / 2
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"Moreover, GSK3beta and FBW7 dependent HIF-1alpha degradation can be antagonized by the USP28 (ubiquitin specific peptidase-28), suggesting that FBW7 and USP28 could reciprocally regulate cell migration and angiogenesis in a HIF-1alpha-dependent manner [XREF_BIBR]."
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eidos
"APC , adenomatous polyposis coli ; DVL , Disheveled ; Fz , frizzled ; GSK3 , glycogen synthase kinase-3 ; LRP , lipoprotein receptor-related ; USP28 , ubiquitin-specific protease 28 As Usp28-deficient mice develop normally , the role of Usp28 in the normal Wnt signaling during embryonic development must be minimal or its absence could be mitigated by unspecified redundant mechanisms , for example , suppressing GSK3beta activity so that TCF7L2 is not ubiquitinated in the first place ."
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