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EGFR phosphorylates itself on Y1069. 13 / 24
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sparser
"Mechanistically, we demonstrated that rLZ-8 bound to EGFR to induce EGFR autophosphorylation at tyrosine1045 and trigger ubiquitination by inducing the formation of EGFR/Cbl complexes, resulting in the degradation of EGFR; however, Cbl-shRNA abolished rLZ-8-induced EGFR degradation."
28198003
sparser
"It was notable that IGF1R knockdown influenced not only EGFR autophosphorylation on Y1045, 1068, 1086, 1145 and 1173, but also the phosphorylation of Y845, a Src-mediated transphosphorylation event ."
17320820
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"Moreover, myricetin has been found to increase EGF-induced autophosphorylation of epidermal growth factor receptor (EGFR) at Tyr845, Tyr992, Tyr1045, Tyr1068, and Tyr1173, as well as inhibit the autop[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26455550
sparser
"We show that in highly motile GIV-wt cells with an intact GEF motif, EGFR autophosphorylation at Y992, Y1045, and Y1068 and the corresponding adaptor recruitment (PLCγ, cCbl, and Grb2) are enhanced, whereas in rapidly proliferating, GEF-deficient GIV-FA cells these events are suppressed."
20462955
sparser
"It is worthy of notice that myricetin increased EGF-induced the autophosphorylation of EGFR at Tyr845, Tyr992, Tyr1045, Tyr1068, and Tyr1173 ( Fig. 3 C, lane 3) although myricetin inhibited the autoph[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18995957
sparser
"Fig 5C: Similar to 2G, EGFR autophosphorylation on Y1068 and Y1045 should also be measured, as well as downstream activation of p42/44 ERK MAPK?"
39937579
sparser
"Following the Reviewer’s request, we have now carried out new experiments to assess the EGFR autophosphorylation on Y1068 and Y1045, as well as downstream activation of p42/44 ERK MAPK."
39937579
trips
"Mechanistically, we demonstrated that rLZ-8 bound to EGFR to induce EGFR autophosphorylation at tyrosine1045 and trigger ubiquitination by inducing the formation of EGFR/Cbl complexes, resulting in the degradation of EGFR; however, Cbl-shRNA abolished rLZ-8-induced EGFR degradation."
28198003
sparser
"By contrast, proproliferative GIV-FA cells showed attenuated EGFR autophosphorylation at Y992, Y1045, and Y1068 but sustained phosphorylation at Y845 ( xref , B and C; and Supplemental Figure S3B)."
20462955
sparser
"Five minutes after EGF addition, EGFR auto-phosphorylation on Tyr 1068 and Tyr 1045 was 2.7- and 1.8-fold greater, respectively, in SEPW1-overexpressing cells compared to empty vector-transfected cont[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25721765
sparser
"Myricetin inhibited the autophosphorylation of endogenous EGFR at Tyr845, Tyr992, Tyr1045, Tyr1068, and Tyr1173 ( Fig. 3 C, lane 4)."
18995957
sparser
"Although further work is needed to define the precise molecular mechanisms of EGFR internalization and degradation, the accumulated evidence suggests the following model of EGF-induced EGFR endocytosis: EGFR that is autophosphorylated at Y1045 within its C-terminal domain recruits and interacts with the TKB domain of c-Cbl."
19489726
sparser
"Promigratory GIV-wt cells displayed enhanced EGFR autophosphorylation at Y992, Y1045, and Y1068, whereas Src-dependent phosphorylation at Y845 was similar to controls ( xref , B and C; and Supplemental Figure S3B)."
20462955