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USP14 inhibits autophagy. 16 / 17
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"Besides, the inhibition of USP14 by IU1-47 induced an increase of the autophagy flux, consistent with the increased degradation rate of Tau [XREF_BIBR]."
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"In addition, it has recently been reported that USP14 negatively regulates autophagy 34, which plays an important role in the regulation of hepatic TG metabolism."
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"Ubiquitin-specific protease 14 promotes radio-resistance and suppresses autophagy in oral squamous cell carcinoma."
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"USP14 is a regulator of de‐ubiquitination and has been reported to be activated through AKT/mTOR pathway and negatively regulate autophagy by K48 de‐ubiquitination in neurodegenerative diseases.32 Hence, we speculated that SPAG5‐AS1 might regulate SPAG5 through USP14.RNA immunoprecipitation analysis confirmed that SPAG5‐AS1 was abundant in USP14‐binding complexes (Figure 6B)."
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"Moreover, we have for the first time demonstrated that the USP14 inhibition induces ER stress mediated autophagy in A549 cells by activation of c-Jun N-terminal kinase 1 (JNK1)."
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"Therefore, this study has demonstrated that typically inhibiting USP14 promotes autophagy in M1 like macrophages and alleviates CLP induced sepsis."
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"Together, it was suggested that SPAG5‐AS1 stabilized SPAG5 protein through interacting with USP14 in HG‐treated HPCs, and that USP14 and AKT/mTOR formed a positive feedback loop.3.7 SPAG5-AS1 promoted apoptosis and attenuated autophagy in HG-treated HPCs through SPAG5/AKT/mTOR pathway."
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"USP14 Suppresses Autophagy by Cleaving Lys63-Ubiquitin Chains from BECLIN 1."
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"On the other hand, it is also possible that the IU1 induced neuroprotection in the post-ischemic mouse brains is a synergistic effect of multiple pathways activated by suppression of USP14 through IU1, since recent results suggest that inhibition of USP14 by IU1 in vitro elevates autophagy activity."
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"Accordingly, pharmacological inhibition of USP14 enhanced autophagy and mitophagy in cultured cells [XREF_BIBR, XREF_BIBR, XREF_BIBR], and USP14 knockdown partially reversed the locomotor deficits in PINK1 and Parkin deficient flies [XREF_BIBR]."
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"Interestingly, it appears USP14 not only negatively regulates the UPS, but also negatively regulates autophagy through removing Lys63 linked ubiquitin chains from the autophagy regulator Beclin-1 [XREF_BIBR]."
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"In conclusion, the current investigation represents a new mechanism by which inhibition of USP14 triggers autophagy via ER stress mediated UPR in A549 cells."
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"USP14 Negatively Regulates Autophagy Induction."
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"According to this observation, it was shown that USP14 suppresses the activity of Beclin1 complex and induction of autophagy by interacting with and controlling K63- rather than K48 linked ubiquitin chains of Beclin1 [XREF_BIBR]."
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"Inhibition of USP14 induces ER stress mediated autophagy without apoptosis in lung cancer cell line A549."
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"Typically inhibiting USP14 promotes autophagy in M1 like macrophages and alleviates CLP induced sepsis."
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