IndraLab

Statements

MDM2 bound to CDKN2A inhibits TP53. 8 / 8
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"As mentioned above, ARF interaction with MDM2 causes MDM2 to target MDMX for degradation, and in the event of mitogenic stimulation MDMX is often downregulated to allow p53 activation."
23002429
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"In the case of MDM2-p53, it is apparent that both mechanisms are observed under different experimental conditions : induced phosphorylation of p53 can attenuate the p53-MDM2 interaction, and alternatively the human protein p14 ARF can bind to MDM2 and prevent its destruction of p53."
15383144
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"Indeed, it has been shown that ARF interacts with MDM2 and prevents MDM2 mediated degradation of p53 [XREF_BIBR]."
20183804
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"When released from nucleoli, Arf binds the central acidic region of MDM2 to inhibit its ubiquitinylation of p53."
25482194
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"The tumour suppressor P19 ARF associates with MDM2 to inhibit the ubiquitination, export and subsequent degradation of p53 [XREF_BIBR, XREF_BIBR]."
16120219
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"In vitro, nuclear p14 ARF binds Hdm2 to block Hdm2 dependent nucleocytoplasmic shuttling of p53, which is required before cytoplasmic degradation of p53."
15318938
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"ARF bound Hdm2 blocks Hdm2 dependent nucleocytoplasmic shuttling of p53, to produce nuclear retention and activation of p53 [XREF_BIBR, XREF_BIBR]."
15318938
reach
"ARF does this by binding to MDM2, a ubiquitin ligase that catalyses p53 degradation; this interaction sequesters MDM2 and also blocks its ligase activity, thereby stabilizing p53."
17439968