IndraLab

Statements

ZUP1 activates pathogenesis. 4 / 4
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"Collectively, this 173 demonstrates that CoV PL pro 's DUB activity enhances virulence in an animal model and that selective 174 removal of this activity could be a basis for the design of MLV vaccines."
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"In summary, coronaviruses PLPs are multifunctional enzymes with cysteine protease, DUB and deISGylating activities that contribute significantly to infection pathogenesis."
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"This study provides the first 35 direct evidence that the DUB activity of a coronaviral protease contributes to innate immune evasion 36 and can profoundly enhance virulence in an animal model."
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"In summary, this indicates that the DUB activity of nsp3 is a major contributor to the pathogenesis of coronavirus infections."
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