IndraLab
Statements
SCN11A activates sodium(1+). 2 / 2
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2
reach
"In particular, while the total density of sodium channels was suggested to increase (Gurtu and Smith, 1988), TTX-resistant sodium currents mediated by Nav1.8 and Nav1.9 appear to be down regulated (Dib-Hajj et al. 1998; Dib-Hajj et al. 1999), whereas the TTX-sensitive current is potentiated, most likely through the up-regulation of Nav1.3 sodium channels (Waxman et al. 1994)."
reach
"While Nav 1.7 may be important by providing ramp currents (acting as a “threshold channel”) and Nav 1.8 has been suggested to be responsible for the “up‐stroke” of action potentials, Nav 1.9 may produce a persistent sodium current and increase the response to subthreshold depolarizations (Dib‐hajj et al., 2010)."