IndraLab

Statements

SCN11A activates sodium(1+). 6 / 6
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"In particular, while the total density of sodium channels was suggested to increase (Gurtu and Smith, 1988), TTX-resistant sodium currents mediated by Nav1.8 and Nav1.9 appear to be down regulated (Dib-Hajj et al. 1998; Dib-Hajj et al. 1999), whereas the TTX-sensitive current is potentiated, most likely through the up-regulation of Nav1.3 sodium channels (Waxman et al. 1994)."
23994814
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"While Nav 1.7 may be important by providing ramp currents (acting as a “threshold channel”) and Nav 1.8 has been suggested to be responsible for the “up‐stroke” of action potentials, Nav 1.9 may produce a persistent sodium current and increase the response to subthreshold depolarizations (Dib‐hajj et al., 2010)."
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"The inward sodium ion current mediated by the Nav1.9 channel plays a crucial role in amplifying subthreshold stimuli and modulating the resting membrane potential of cells (Dib-Hajj et al., 2015)."
40206072
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"Instead of using active metal, sodium azide (NaN ) could be applied to produce sodium followed by reducing hexachlorobenzene (C Cl ), which had been proven to be a feasible approach as well."
35423208
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"Endogenous sodium currents are mainly mediated by Nav1.6 and Nav1.7, but also Nav1.1, Nav1.2, Nav1.3 and Nav1.9 at low levels ( Lee et al., 2019 )."
38657946
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"The reaction between 2-pyridylselenyl reagents and NaN(CN) 2 in a 2:1 ratio produces the sodium complexes featuring the cationic selenium-containing triazapentadiene (SeTAP) ligand."
39008809