IndraLab

Statements

Aldehyde binds Ubiquitin and USP14. 2 / 2
| 2
reach
"In the USP14/ubiquitin-aldehyde complex, where the ubiquitin C terminus is covalently bound to the site cysteine and only one C-terminal oxygen is present, Asn108 (Asn218 in USP2) interacts with the hydroxyl of the thiohemiacetal, while Asn111 (Asn221 in USP2) makes no specific interactions and is rotated away from the active site."
16905103
reach
"However, as the USP14/ubiquitin-aldehyde complex (Hu et al., 2005) has been solved at significantly lower resolution than the corresponding complex with USP7 (3."
16905103