IndraLab

Statements

PAN2 deubiquitinates RBBP8. 3 / 3
1 1 | 1
signor
"Here, we identify that USP52 directly interacts with and deubiquitinates CtIP, thereby promoting DNA end resection and HR. Mechanistically, USP52 removes the ubiquitination of CtIP to facilitate the phosphorylation and activation of CtIP at Thr-847. In addition, USP52 is phosphorylated by ATM at Ser-1003 after DNA damage, which enhances the catalytic activity of USP52."
33097710
reach
"USP52 directly interacts with and deubiquitylates CtIP to promote DNA end resection and HR [118]."
33990032
ubibrowser
"Mechanistically, <span class="match term0">USP52</span> removes the ubiquitination of <span class="match term1">CtIP</span> to facilitate the phosphorylation and activation of <span class="match term1">CtIP</span> at Thr-847"
33097710