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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

MTOR phosphorylates IRS1 on S616. 2 / 2

1 | 1

➶

signor

"Mtor induced the serine phosphorylation of irs-1 (ser-636/639), and such phosphorylation was inhibited by rapamycin. These results suggest that tnf impairs insulin signaling through irs-1 by activation of a pi 3-kinase/akt/mtor pathway, which is antagonized by pten"

11287630

➶

reach

"In addition, activation of the PI3K pathway results in feedback down-regulation of pathway signaling, mediated by an mTOR and S6K phosphorylation and inhibition of IRS-1 at Ser612 XREF_BIBR, XREF_BIBR, XREF_BIBR."

22570710

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...