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TP53 increases the amount of mutated TP53. 8 / 8
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"For example, P53 missense mutations increases the expression of mutant p53 proteins, which, in turn, decreases the infiltration of cytotoxic CD8 T cells in pancreatic cancer [80]."
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"Thus, discovery of BMI1 inhibitor and PTEN activating molecules will be beneficial for the effective anti-cancer therapy.Silencing mutant p53 expression by p53 specific siRNA in several human cancer c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus we determined the need to isolate single cell DLD1 clones with p53-EGFP reporter expression that have fairly low basal EGFP expression and that could be induced to high EGFP expression upon exposure to small molecules that restore p53 pathway signaling in mutant p53 expressing DLD1 cells."
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"It is important to note that no prior study has linked p53 or p73 to the mechanism of action of either prodigiosin or its related structures and no prior study has demonstrated the ability of these compounds to restore p53 pathway signaling in mutant p53 expressing or p53-null cancer cells."
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"MKP-1 has been shown to be transcriptionally regulated by p53, and mutations of p53 abrogate p53 dependent transcription of MKP-1 in vitro (Yang and Wu, 2004; Liu et al, 2008)."
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"These results suggest that NSC59984 restores p53 pathway signaling in mutant p53 expressing SW480 and DLD-1 human colorectal cancer cells."
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"NSC59984 specifically restores p53 pathway signaling in mutant p53 expressing human colorectal cancer cells."
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"XREF_BIBR In addition to CDKN1A and p21 CIP1, other traditional p53 targets, such as GADD45 and 14-3-3sigma, also were up-regulated but perhaps not as a result of p53 activation given that 779e cells express no detectable p53 protein and that E47 repressed the expression of mutant p53 mRNA and protein in the other 4 lines (XREF_FIG A-F)."
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