IndraLab

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RUNX1 decreases the amount of RUNX1. 27 / 33
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"AML1–ETO represses transcription of AML1 and blocks differentiation of hematopoietic stem and progenitor cells by the interaction between ETO and the human N-CoR/mSin3/HDAC1 complex [13–18] ."
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"The concomitant decrease in committed progenitors in Runx1 lz/+ embryos (Cai et al., 2000; Mukouyama et al., 2000; Wang et al., 1996a, 1996b) is consistent with a model that reduced Runx1 dosage cause[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Correspondingly, RUNX1 protein expression was significantly inhibited by RUNXOR siRNA or RUNX1 siRNA as determined by flow cytometry (Fig.2M)."
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"Runx1 expression was decreased specifically by Runx1 shRNA but not by the vector containing a control hairpin; in addition, this Runx1 specific shRNA did not influence the expression of Runx2 or Runx3."
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"In contrast, kidneys of Runx1 cKO mice had significantly decreased mRNA expression levels of Runx1, Col1a1, Col3a1, Pai-1 and Fibronectin after UUO induction when compared to those in WT mice (XREF_FIG b)."
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"Conversely, RUNX1 and AML1 siRNAs specifically down-regulated RUNX1 and AML1 protein levels by 50%-80% without any effect on AML1-ETO (XREF_FIG)."
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"Moreover, our preliminary experiment showed that the knockdown of Runx1 expression by Runx1 siRNA decreased the level of Xlr5c like mRNA in granulosa cell cultures, suggesting that RUNX1 is involved in Xlr5c like expression (XREF_SUPPLEMENTARY)."
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"We investigated whether the RUNX1 siRNA cocktail (siRUNX1) could effectively suppress the expression of RUNX1 in UT-7/GM cells."
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"In contrast, in CBF leukemias the dimerization domains of the partners of AML1, which include TEL, ETO, and MTG16, repress the transcription of AML1 target genes by either recruiting HDACs directly or by recruiting co-repressor-HDAC complexes such as N-CoR/Sin3/HDAC1 to AML1 responsive promoters."
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"This observation provides a mechanism for how the AML1 and ETO fusion may inhibit expression of AML1 responsive target genes and disturb normal hematopoiesis."
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"Runx1 protein levels decreased to 88%, 59%, and 47% in 14-, 22-, and 34-week hearts, respectively, relative to the protein level at the 10-week time point (Fig. 1C and D), suggesting a progressive decline of Runx1 expression with increasing age."
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"Increased expression of RUNX1 is thought to contribute to chemotherapy resistance by upregulating anti-apoptotic genes in AMegL, and decreased expression of RUNX1 in vitro has been shown to increase A[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"RUNXOR interacts with the promoters and enhancers of the RUNX1 gene, which negatively regulates RUNX1 expression, which leads to enhance immunosuppression of MDSCs."
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"Injection of AML1 and MTG8 RNA and ribozyme RNA into Xenopus eggs or oocytes causes a specific reduction of AML1 and MTG8 protein expression."
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"RUNX1 pathway-associated activation of the ACE2 and FURIN expression may trigger the auto-regulatory negative feed-back loop of the FURIN-mediated repression of the RUNX1 gene expression (C)."
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"Co-transfection of RUNX1 expression plasmid with FBW7 expression plasmid greatly diminished RUNX1 protein level indicating decreased RUNX1 stability and increased RUNX1 degradation, consistent with activation of the ubiquitin proteasome system by increased production of FBW7."
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"XREF_BIBR, XREF_BIBR t (8; 21) fuses the RUNX1 gene (AML1) on chromosome 21 to the ETO gene (RUNX1T1) on chromosome 8, encoding the RUNX1 and ETO chimeric transcription factor that represses expression of RUNX1 target genes, promoting self-renewal and blocking myeloid differentiation."
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"RUNX1 downregulation using non variant selective siRNA decreased expression of RUNX1 and PCTP mRNA and protein (XREF_FIG)."
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"The AML1 -ETO specific siRNAs inhibited AML1 -ETO expression at both mRNA and protein levels."
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"RUNX1 gene silencing induces p53-promoted core binding factor-beta (CBFB) expression, and upregulated CBFB stabilizes RUNX1 expression in acute myeloid leukaemia cells, resulting in a compensatory RUNX1-p53-CBFB feedback loop (Morita et al., 2017)."
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"Depletion of RUNX1 protein by siRNA in hematopoietic cells, significantly reduces RUNX1 occupancy at these sites, as well as transcription of the RUNX1 gene."
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"High HIF1α levels were correlated with increased AML1/ETO levels, and predicted inferior survival in t(8;21) AML patients.Perturbations of the transcription factors AML1 and ERG prevent the overexpression of the AML1/ETO oncogene and the onset of the apoptosis program in t(8;21) AMLs [70]."
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"Our data suggests that the RUNX1 L472X mutant may inhibit the transcription or translation of wild type RUNX1 protein, possibly leading to the type of dominant negative effect that has been associated with a higher risk of leukemia in some FPDMM families."
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"Our results confirmed that over-expression or downregulation of FoxO3a, respectively, resulted in the up- or down-regulation of Sox9, and we further found the downregulation of RUNX1 or FoxO3a inhibit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The increased runx1 expression in the ICM of the Gata1 morphant suggests that Gata1 may normally inhibit the expression of runx1 ."
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"Importantly, RUNX1 knockdowns in THP-1 cells did not reduce target gene expression, and in some cases actually increased expression of RUNX1 target genes (XREF_FIG D)."
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"Unlike Ptgs2 expression, we found that reduction (~ 45%) of Runx1 expression by Runx1 siRNA had no effect on Tnfaip6 expression in preovulatory granulosa cell cultures (XREF_SUPPLEMENTARY)."
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