IndraLab
Statements
reach
"High HIF1α levels were correlated with increased AML1/ETO levels, and predicted inferior survival in t(8;21) AML patients.Perturbations of the transcription factors AML1 and ERG prevent the overexpression of the AML1/ETO oncogene and the onset of the apoptosis program in t(8;21) AMLs [70]."
reach
"In contrast, in CBF leukemias the dimerization domains of the partners of AML1, which include TEL, ETO, and MTG16, repress the transcription of AML1 target genes by either recruiting HDACs directly or by recruiting co-repressor-HDAC complexes such as N-CoR/Sin3/HDAC1 to AML1 responsive promoters."
reach
"XREF_BIBR, XREF_BIBR t (8; 21) fuses the RUNX1 gene (AML1) on chromosome 21 to the ETO gene (RUNX1T1) on chromosome 8, encoding the RUNX1 and ETO chimeric transcription factor that represses expression of RUNX1 target genes, promoting self-renewal and blocking myeloid differentiation."