IndraLab

Statements

CTNNB1 acetylates CTNNB1. 2 / 3
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"As also shown in Figure 7A , Aspirin caused a marked increase in acetylated β-catenin (Lys-49) but a slight increase in GSK-3β, whereas LiCl caused a slight decrease in acetylated β-catenin but a marked decrease in GSK-3β."
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"Because the affinity of beta-catenin for TCF4 increases when beta-catenin is acetylated, XREF_BIBR, XREF_BIBR and beta-catenin mediates Wnt signaling by recruiting transcriptional cofactors, such as p300 and CBP, 15 both of which can function as acetyltransferases, we investigated whether Bach1 may disrupt the interaction between beta-catenin and p300 and CBP and if so, whether this disruption inhibits beta-catenin acetylation."
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