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OTUB1 inhibits DDX58. 1 / 1

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"Coimmunoprecipitation analyses indicate that OTUB1 and OTUB2 associate with TRAF3 and TRAF6, negatively regulating antiviral responses by deubiquitinating their respective K63-linked polyubiquitin chains. [172] Because various components are involved in virusinduced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG-I-, MDA5-, and MAVS-mediated but not TBK1-and IRF3-mediated signaling."

33511009

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IndraLab

Statements

OTUB1 inhibits DDX58. 1 / 1

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