IndraLab

Statements

NPM1 is phosphorylated on S125. 61 / 61
36 | 22 3
hprd
No evidence text available
18491316
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17322306
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20068231
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19413330
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19007248
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20166139
sparser
"These results suggest that Aurora-B promotes OS cells malignancy in-part, by phosphorylating NPM1 Ser125 ."
32606971
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No evidence text available
17287340
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17287340
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No evidence text available
19007248
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No evidence text available
20230923
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20230923
sparser
"We initially measured the basal levels of NPM, NCL, p53 and p53 phosphorylated at Serine 15 and at Serine 392 as well as NPM phosphorylated at Serine 125."
21499441
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20230923
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17287340
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19562805
sparser
"The oligomerization of NPM1 is facilitated by the phosphorylation of NPM1 at Ser125, which is a substrate of IKKα [ xref ]."
33040459
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No evidence text available
18491316
sparser
"Aurora-B was found to promote OS cell growth and metastasis through its ability to phosphorylate NPM1 Ser125 and activate ERK/NF-κβ signaling."
32606971
rlimsp
"Interestingly, the hypophosphorylated form of NPM (3A) augmented this expression even further. Consistently, this NPM mutant could highly activate the E2F1 promoter activity, as shown by a reporter assay (Figure 4B). In contrast, expression of the phosphomimetic variant (3D) did not result in any significant alteration of the E2F1 mRNA level (Figure 4A). Another phosphodefective mutant that was altered on one of the MS-identified phosphorylation sites (S125A) also did not further activate E2F1 promoter activity compared with wild-type NPM (Supplemental Figure S4C), suggesting a lack of involvement of this residue in this functional aspect."
20962268
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No evidence text available
20058876
sparser
"As expected, in both AML cell lines we detected the inhibition of CK2-mediated phosphorylation at S125 residue of NPM1 by Western blot ( xref )."
| PMC
sparser
"Aurora-B promotes NPM1 phosphorylation on Ser125."
32606971
sparser
"Downregulation of NPM1's Ser-125 phosphorylation was further confirmed using Western blot."
36563749
rlimsp
"Interestingly, although CacyBP/SIP exhibits phosphatase activity, we have found that its overexpression favors phosphorylation of NPM1 on S125."
29806702
hprd
No evidence text available
19413330
sparser
"These data suggest that the inability to activate PP1 in AT cells ( xref )could be responsible for the chronic expression of NCL and NPM phosphorylated at Serine 125."
21499441
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18691976
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18452278
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19562805
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No evidence text available
20166139
sparser
"Aurora-B Activates ERK/NF-κβ Signaling Through the Phosphorylation of NPM1 Ser125 ."
32606971
hprd
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20058876
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19562805
sparser
"Aurora Kinases A and B phosphorylate NPM1 at S125, which plays a major role in cytokinesis."
29157973
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18452278
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17322306
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20068231
sparser
"Once activated, PP1 represses NPM Ser125 phosphorylation and NCL levels."
21499441
sparser
"Our data indicate that down regulation of PP1 in ATM corrected cells ( xref ) returned the levels of NPM phosphorylated at Serine 125 and NCL to the high basal levels observed in ATM deficient cells."
21499441
sparser
"Phosphorylation of nucleophosmin (NPM1) at Ser-125 residue in PPARα/RXRα pathway was significantly reduced (>20-fold, p=1.37×10 -9 ), followed by the reduced phosphorylation of transforming growth factor-beta 2 at Ser-46 (TGF-β2, >12-fold, p=1.37×10 -3 )."
36563749
sparser
"Nonetheless, the NPM Serine 125 phosphorylation is specific since the NPM fragments 1–180 and 175–222 are not phosphorylated by Cdc2 ( xref )."
21499441
hprd
No evidence text available
20068231
hprd
No evidence text available
17322306
sparser
"Aurora-B promotes OS malignancy via phosphorylating NPM1 Ser125 and activating ERK/NF-κβ signaling."
32606971
sparser
"Interestingly, although CacyBP/SIP exhibits phosphatase activity, we have found that its overexpression favors phosphorylation of NPM1 on S125."
29806702
sparser
"NPM phosphorylation at Ser125 could impact DNA repair indirectly by competing out with p53 for remaining active kinases in ATM deficient cells ( xref )."
21499571
hprd
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18452278
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20058876
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19007248
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No evidence text available
19413330
hprd
No evidence text available
18691976
sparser
"Our data ( xref ) indicate that NPM is hyperphosphorylated at Ser125 in AT cells and that overexpression of a functional ATM in AT cells reduces NPM phosphorylation to the levels of normal cells."
21499571
sparser
"Kinases such as ATR and hSMG1 ATX ( xref ), and perhaps CK2, are most likely responsible for the NPM Serine 125 constitutive phosphorylation in AT cells."
21499441
sparser
"Collectively, these results suggest that Aurora-B promotes NPM1 phosphorylation on Ser125."
32606971
hprd
No evidence text available
18691976
hprd
No evidence text available
20166139
hprd
No evidence text available
18491316
sparser
"These results suggest that Aurora-B activates ERK/NF-κβ signaling via phosphorylating NPM1 Ser125 ."
32606971
rlimsp
"We have found that Aurora kinases A and B can phosphorylate NPM1 at a single serine residue, Ser125, in vitro and in vivo."
24857377
sparser
"Here we show that the levels of Nuclephosmin (NPM), NPM phosphorylated at Serine 125, p53, p53 phosphorylated at Serine 15 and Serine 392 and the levels of Nucleolin (NCL) are high in AT fibroblasts compared to normal cells."
21499441