IndraLab

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KRAS activates MAPK1. 8 / 15
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"KRAS also activates ERK2 protein by upregulating ERK1."
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"Another one is that mutant Kras-activated ERK2 directly phosphorylates SNAIL [ xref ]."
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"In vitro phosphorylation assays revealed that EGFP-K-Ras (V12) enhanced the activity of HA-ERK-2 by a factor of 3.3 +/- 0.37 (+/- SD, n = 5) compared to mock transfected controls."
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"By the nanoimmunoassay (NIA), KRAS is found to activate the protein ERK2, whereas ERK1 activation is found in non-KRAS-associated human lung tumors."
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"KRAS proto-oncogene, GTPase (KRAS) mutations activate mitogen activated protein kinase 1 (ERK) and then promote the degradation of FBW7 through the ubiquitin-proteasomes pathway in a phosphorylation dependent manner, sequentially abrogating the function of FBW7 as a tumor suppressor."
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"KRAS also activates ERK2 protein by upregulating ERK1."
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"Indeed, both K-RAS mutant PC cell lines and resected tumor patients showed high levels of p-DRP1 on Ser616, mediated at least in part by K-RAS-dependent activation of ERK2 kinase."
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"Here, HLD contributed to fibro-inflammatory responses in the pancreas.Oncogenic activated Kras promotes downstream stimulation of COX2, phosphor-ERK, and macrophage infiltration in the area surrounded by the pancreas’ neoplastic lesion leading to the motivation of the formation of pancreatic intraepithelial neoplasia [227]."
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