IndraLab

Statements

BAP1 increases the amount of BAP1. 7 / 7
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"BAP1-IP3R3 CoIP was barely detectable in BAP1 +/- fibroblasts; BAP1 rescue significantly increased the amount of BAP1 that CoIP with IP3R3 (XREF_FIG)."
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"Mechanically, we show that BAP1 represses metabolic stress induced UPR and cell death through activating transcription factor 3 (ATF3) and C/EBP homologous protein (CHOP), and reveal that BAP1 binds to ATF3 and CHOP promoters and inhibits their transcription."
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"Deletion of chromosome 3 and BAP1 inactivating mutations cause loss of BAP1 expression and function in cancer."
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"DIM promotes proliferation and osteogenic differentiation of MC3T3-E1 cells in vitro, and also plays a bone promoting role by increasing the interaction between BRCA1-Associated Protein 1(BAP1) and Inositol 1,4,5-Trisphosphate Receptor(IP3R), up-regulating the expression of BAP1 and IP3R and downstream storage operation calcium entry (SOCE) related protein Recombinant Stromal Interaction Molecule 1(STIM1)."
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"We also detect the mRNA and protein expression level of BAP1, tumors with BAP1 plasmid transfected group exhibited higher BAP1 mRNA and protein expression compared with the control group, suggesting that BAP1 plasmid overexpression could rescue the expression of BAP1 suppressed by miR-31."
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"Genetic mutations in BAP1 could modulate BAP1 protein expression or could alter BAP1 function in the absence of alterations in protein expression."
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"Furthermore, qRT-PCR and western blotting revealed that BAP1 mRNA and protein levels were notably enhanced in HCT116 and RKO cells by miR-593-3p inhibitor transfection, whereas miR-593-3p mimic apparently restrained BAP1 expression (Fig. 4E and F)."
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