IndraLab

Statements

TBK1 binds CYLD. 9 / 9
3 | 5 1
reach
"We further demonstrated that Optn mediated recruitment of the deubiquitinase CYLD to TBK1 is responsible for this inhibitory effect."
25923723
reach
"As expected, formation of the TBK1 and CYLD complex was also reduced during the G2/M phase, while CYLD-Optn interaction remained unaffected as shown by co-immunoprecipitation and in situ PLA experiments performed in RO treated cells (Fig XREF_FIG, XREF_FIG and XREF_FIG, middle and lower panels, respectively)."
25923723
biogrid
No evidence text available
18636086
reach
"CYLD also binds to TBK1 and CYLD -/- DCs show constitutive activation of TBK1."
24493797
sparser
"Disruption of the interaction between TBK1 and CYLD should lead to higher ubiquitination levels of this kinase and consequently to its hyperactivation."
25923723
reach
"Disruption of the interaction between TBK1 and CYLD should lead to higher ubiquitination levels of this kinase and consequently to its hyperactivation."
25923723
reach
"Interestingly, the number of PLA specific dots observed using anti-TBK1 and anti-ubiquitin antibodies was increased in RO treated cells compared to untreated cells (XREF_FIG), strongly suggesting that disruption of the TBK1 and CYLD interaction during the G2/M transition led to increased ubiquitination of TBK1 and therefore to its activation [XREF_BIBR]."
25923723
biogrid
No evidence text available
25923723
biogrid
No evidence text available
25923723