IndraLab

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"Since the PUB domain mediates the interaction with CYLD and OTULIN (Schaeffer et al , xref ; Takiuchi et al , xref ; Draber et al , xref ) and the ZF and NZF1 are required for HOIP binding to ubiquitin and NEMO (Haas et al , xref ; Ikeda et al , xref ; Fujita et al , xref ), we hypothesised that cleavage of HOIP may modulate TRAIL‐induced gene activation."