IndraLab

Statements

CCND1 binds CDK4, CDK6, and RB1. 4 / 4
1 | 3
sparser
"We found that high expression of CDK4, CDK6, CCND1, and phospho-RB1 was associated with higher proliferative index, as defined by MKI67."
28991877
hprd
No evidence text available
9380698
sparser
"The proliferation-promoting action of isoprenaline was abolished by a β1-selective antagonist and was more effectively abolished by a β2-selective antagonist; the mechanism for the action of the antagonists was a G0/G1 phase cell cycle arrest which was associated with decreased cyclin D1, CDK-4, CDK-6 and phospho-Rb expression."
23286511
sparser
"As a key mediator of cell cycle progression, cyclin D1 forms complex with cyclin-dependent kinase 4 (CDK4) and CDK6 to inactivate the retinoblastoma (RB) pathway via hyperphosphorylation of the RB protein and result in acceleration of E2F-mediated gene transcription xref ."
28602785