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CYLD activates Interferon. 8 / 8
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"Collectively, our results indicated that IFNγ-stimulated caspase-8 and CYLD upregulation additively promoted TNF/IFNγ-induced cell death in cancer cells."
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"Experimental knockout of CYLD reduced IFN-mediated signaling and expression of IFN-inducible genes (Zhang et al. 2011)."
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"In addition, Xu et al. reported that RIG-I activity is mediated by miR-526a through inhibition of CYLD expression, which negatively regulates generation of type I interferon (Xu et al., 2014)."
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"For example, the DUB enzyme cylindromatosis (CYLD) was shown to directly bind RIG-I and mediate the removal of K63-ub and limit IFN induction [XREF_BIBR]."
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"CYLD knockdown also significantly inhibited TNF/IFNγ-induced cell death (Fig. 3, E and F), and combined knockdown of caspase-8 and CYLD inhibited TNF/IFNγ-induced cell death in an additive manner (Fig. 3, G and H)."
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"It was initially believed that CYLD inhibited IFN signaling by deubiquitinating the PRR, RIG-1, and downstream kinases TANK binding kinase 1 (TBK-1) and inhibitor of NF-kappaB kinase Epsilon (IKKEpsilon) 44; but, surprisingly, IFN response to vesicular stomatitis virus in CYLD knockout mice or cells from these mice was abrogated.45 On the basis of these reports, TRAF3 and CYLD may serve similar functions after viral infection, namely, to inhibit NF-kappaB and activate IFN."
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"Similarly, knockdown CYLD in EMT6 cells and in murine BMDMs inhibited TNF/IFNγ-induced death (Fig. S4, A–D)."
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"Release of the CYLD mediated inhibition of TBK1 during this phase results in enhanced IFN and ISG signaling pathway, independently of viral infection."
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