IndraLab

Statements


| 6

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"Ethanol-induced BK channel inhibition is increased with age."

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"Another intriguing possibility would be that excessive cholesterol directly interferes with EtOH-sensing site(s) on BK channel protein precluding EtOH-induced BK channel inhibition."

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"Ethanol-induced BK channel inhibition is independent of alcohol metabolism and freely diffusible cytosolic signals."

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"Ethanol-induced BK channel inhibition in inside-out patches excised from freshly isolated cerebral artery myocytes was also abolished by cholesterol enrichment."

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"Ethanol-induced BK channel inhibition could be clearly observed during the 3–7 min of ethanol application."

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"Therefore, BK channel inhibition by EtOH results in arterial constriction."