IndraLab

Statements

NPM1 is phosphorylated on T237. 6 / 16
2 | 6 8
sparser
"The only exception was NPM1, which was exclusively phosphorylated at Thr237 but not Ser70 using recombinant protein, in contrast to the results from crude extracts."
35291876
sparser
"Biochemical and immunocytochemistry analyses verified that the phospho-MKK1/MKK2 antibodies cross-reacted with NPM that was phosphorylated at Thr234 and Thr237 during G2/M-phase, which are the same sites that are targeted by Cdc2 (cell division cycle protein-2) during mitosis."
14670079
sparser
"Since NPM is phosphorylated on Thr234 and Thr237 by cyclin-dependent kinase (CDK) 1/cyclinB [ xref ], we tested whether knockdown of CDK1 had a role in the regulation of p-NPM-Thr 234/237 mediated HCC metastasis."
26536659
sparser
"Accompanied with the reduction in CDK1 expression, p-NPM-Thr 234/237 was consistently suppressed in two shCDK1 clones when compared to NTC control, which suggesting that CDK1 is upstream kinase leading to NPM phosphorylation at Thr234 and Thr237 (Figure xref )."
26536659
sparser
"In particular, there were marked decreases in the phosphorylation of nucleophosmin at Thr-199, Thr-234 and Thr-237 ( Tarapore et al., 2006 ), which are catalyzed by cyclin-dependent kinase (CDK)1 and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17166628
sparser
"CDK-1 mediated phosphorylation of NPM1 at T199, T219, T234 and T237 has been shown to play a critical role in mitosis [42] ."
29157973