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OTUB1 activates Neoplasms. 21 / 21
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"Therefore, in various malignant tumors, OTUB1 acts as a pro-oncogene and promotes tumor progression."
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"26 We have also found that OTUB1 promotes tumour progression with an abnormally increased expression in ovarian cancer ."
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"In this context, OTUB1 might be a potential target for new therapies of OSCC.As a key and star deubiquitinating enzyme, OTUB1 mediates ferroptosis, immunity, apoptosis, and autophagy in tumor and non-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Specifically, the deubiquitinating enzymes OTUB1 [138], OTU deubiquitinase 5 (OTUD5) [32,139], and ubiquitin specific peptidase 31 (USP31) [140] remove ubiquitination, inducing subsequent proteasomal degradation of GPX4, thus inhibiting ferroptosis-mediated tissue injury or tumor progression."
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"OTUB1 has been proposed to promote the progression of myeloma (24), colorectal (9), prostate cancer (10), ovarian cancer (28), gastric cancer (12), HCC (12), and glioma (15) by facilitating tumor invasiveness."
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"The xenograft model showed that OTUB1 depletion significantly reduced tumor growth in vivo (Fig. 3N, O, R)."
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"In vivo experiments revealed that OTUB1 knockdown inhibited tumor growth, further emphasizing its crucial role in GBM progression."
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"In the xenograft mice model, OTUB1 depletion inhibited tumor growth, which effect could be rescued by YAP over-expression in MKN28 cells (Fig. 4Q, S)."
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"In multiple myeloma, OTUB1 promoted tumor survival by removing the K48-linked polyubiquitination chain from c-Maf to facilitate the transcription of oncogenes [16]."
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"As the activation of c-MYC contributes to the progression of multiple types of cancer, this study implies a general tumor-promoting role of OTUB1."
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"Notably, OTUB1 overexpression led to the largest tumors in the tongues by orthotopically transplantation into the tongues of nude mice (Figure 2C,D)."
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"And IHC staining of OTUB1, KI67, RACK1, p-ERK, p-AKT, and p-FAK supported that efficient OTUB1 knockdown ameliorated the hyperactivation of the oncogenic pathway (Fig. 3f, g), and corroborated the reduced subcutaneous tumor growth when OTUB1 silenced."
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"Cancer cells overexpress deubiquitinase OUT deubiquitinase ubiquitin aldehyde binding 1 (OTUB1), which stabilizes cystine transporter SLC7A11, inhibits ferroptosis and promotes tumor growth (162)."
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"OTUB1 promotes tumor progression in two ways : to stabilize the expression of oncogenic genes by inhibiting the ubiquitination of target protein , and the other mode does not depend on the deproteinization manner ( Saldana et al ., 2019 ) but directly interacts with E2 ubiquitin ligase ."
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"Knockdown of OTUB1 inhibited tumor oncogenicity in vivo."
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"As depicted in Figure 3a, OTUB1 overexpression significantly promoted tumor cellular migrative capacity (Figure 3b)."
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"Moreover, subsequent WB and qRT-PCR test provided intriguing evidences that OTUB1 overexpression also considerably enhanced stem-cell markers of CRC tumor including CD133 and CD44 (Figure 4g-h)."
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"They revealed that OTUB1 knockdown significantly inhibited tumor growth.Furthermore, western blot analysis revealed that OTUB1 promoted GBM through facilitating EMT."
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"Subsequent experiments further suggested that OTUB1 promoted CRC malignancy by enhancing protein stability of beta-catenin , via inhibition of its protein degradation by UPP pathway , which indicated its crucial role in enhancement of CRC tumor cellular proliferative and chemo-resistant capabilities ."
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"For example, the deubiquitinase OTUB1 is abnormally upregulated in cancer cells and promotes tumor development to suppress ferroptosis by stabilizing the cystine transporter SLC7A11, which uptakes cystine and exports glutamate."
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"Despite a recent report that OTUB1 stabilizes MDMX and induces apoptosis 46, OTUB1 stabilizes proteins linked to cancer progression such as RAS and FOXM1 via deubiquitination and promotes tumor growth and invasion 34,47."
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