IndraLab

Statements

OTUB1 activates Neoplasms. 3 / 3
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"Subsequent experiments further suggested that OTUB1 promoted CRC malignancy by enhancing protein stability of beta-catenin , via inhibition of its protein degradation by UPP pathway , which indicated its crucial role in enhancement of CRC tumor cellular proliferative and chemo-resistant capabilities ."
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"26 We have also found that OTUB1 promotes tumour progression with an abnormally increased expression in ovarian cancer ."
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"OTUB1 promotes tumor progression in two ways : to stabilize the expression of oncogenic genes by inhibiting the ubiquitination of target protein , and the other mode does not depend on the deproteinization manner ( Saldana et al ., 2019 ) but directly interacts with E2 ubiquitin ligase ."
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