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ESR2 decreases the amount of ESR1. 24 / 31
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"We predicted that ERbeta activation would increase prosocial behavior, decrease aggression and reduce ERalpha expression in the MEApd and BSTpm of males; however, as control juveniles were expected to be highly prosocial, these behavioral effects might be obscured by an apparent " ceiling effect "."
26222494
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"And recent studies suggest that high ERbeta content can down-regulate the expression of ERalpha."
29875657
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"In summary, these findings collectively suggest that primarily ERalpha promoter C may mediate ERbeta mediated inhibition of ERalpha expression in endometriotic stromal cells (XREF_FIG)."
22772552
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"However, binding of ERbeta suppresses ERalpha mediated gene transcription, and accordingly, the mouse knockouts of either receptor show completely opposing phenotypes [XREF_BIBR]."
17464358
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"Thus, we hypothesize that ERbeta upregulation of HER2 could be related to reduced ERalpha action by the formation of ERalpha and ERbeta heterodimers, which relieves ERalpha homodimer mediated repression of HER2 expression, and/or by ERbeta repressing the expression of ERalpha, as seen in our cell models."
21492444
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"Indeed, we report that ERbeta could reduce more rapidly and strongly the expression of ERalpha in BG-1 cells in the presence of E2, compared to cells in which only ERalpha is present."
22970307
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"Indeed, we observed that endogenous ERalpha levels in BG-1 cells were strongly reduced by the presence of ERbeta, whereas ERbeta affected less ERalpha levels in PEO-14 cells."
22970307
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"As activation of ER-beta decreases ER-alpha expression 58, it may be possible that downregulation of ER-alpha contributed to these observations."
26949527
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"The presence of ERbeta strongly diminished ERalpha levels in the presence of E2 (more than 15 fold decrease in 3 h), suggesting that ERbeta enhances the degradation of ERalpha."
22970307
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"ERbeta suppresses ERalpha expression and results in strikingly high ERbeta-to-ERalpha ratios in endometriotic cells."
20104427
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"ESR2, which is upregulated in OE, has been shown to suppress ESR1 expression in endometriosis by binding to the ESR1 promoter [XREF_BIBR, XREF_BIBR]."
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"ESR2 represses ESR1 expression by directly binding to its promoter, which can result in progesterone resistance [XREF_BIBR, XREF_BIBR]."
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"It has been hypothesized that ESR2 suppressed ESR1 expression in endometriotic cells in culture by binding to classical and nonclassical cis-regulatory elements in specific promoters of the ESR1 [XREF_BIBR]."
32316608
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"% Estrogen receptor (ER) beta counteracts the activity of ERalpha in many systems."
14745018
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"In contrast, ERbeta can repress ERalpha expression, and mice lacking ERbeta have increased ERalpha in their bones."
23362266
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"Bossard et al. have confirmed that ERbeta can repress the expression, activity and signaling of ERalpha, thusly blocking its proliferative action (Bossard et al., 2012)."
24189439
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"The increased level of ERbeta decreases the level of ERalpha by downregulating its transactivation [XREF_BIBR]."
33562134
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"ER-beta suppresses ER-alpha levels."
24179489
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"High levels of ERbeta suppress ERalpha expression."
22271293
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"It has been demonstrated that when co-expressed in breast cancer cells, ERbeta antagonizes the expression of ERalpha mediated expression of growth regulatory genes, including c-Myc and cyclin D1."
20424134
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"Treatment with DPN (an ERbeta agonist) also decreased ERalpha and ERbeta mRNA levels at 3 h (XREF_FIG) and 6 h (XREF_FIG)."
24334513
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"The down-regulation of ERalpha expression by ERbeta may not be the only mechanism of growth inhibition by ERbeta, as ERbeta can also reduce cell growth of ERalpha negative PEO-14 cells."
22970307
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"ERbeta suppresses ERalpha expression and results in strikingly high ERbeta-to-ERalpha ratios in endometriotic cells."
22772552
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"Increased ERbeta and ERalpha ratios prevented ligand dependent downregulation of ERalpha transcription, resulting in reduced proliferation in old-donor hOBs."
12111994