IndraLab

Statements

DHS-I activates KCNMA1. 3 / 3
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"Isolation of natural occurring compounds revealed several BK channel activators including DHS-I that was found to dramatically increase the open probability of smooth muscle BK channels when applied to the intracellular site."
25346695
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"If DHS-I and estradiol also activate Slo1 core and Slo3 tail channels only in the presence of the beta1 subunit, then this would suggest that the beta1 subunit is also functionally associated with Slo1 core and Slo3 tail channels."
12451052
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"[XREF_BIBR] However, BK channel activation by DHS-I requires compound application from the intracellular side of the membrane, [XREF_BIBR] which represents a shortcoming for the administration of DHS-I in the intact organism."
22945504