IndraLab

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BAP1 deubiquitinates OGT. 5 / 5
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"To investigate whether BAP1 can deubiquitylate and stabilize OGT directly, rather than decreased OGT being secondary to a reduction in HCF-1, we affinity purified ubiquitylated and Myc tagged human OGT from HEK293T cells, and then incubated it with human BAP1 and human ASXL1 residues 2-365 co-purified from Sf9 cells."
22878500
ubibrowser
"The tumor suppressor <span class="match term0">BAP1</span> associates with ASXL1/2 to form the core Polycomb complex PR-DUB, which catalyzes the removal of mono-ubiquitin from several substrates including histone H2A. This complex also mediates the poly-deubiquitination of HCFC1, <span class="match term1">OGT</span> and PCG1-alpha, preventing them from proteasomal degradation."
29069806
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"OGT is a well-known protein associated with BAP1 in the BAP1 core complex, which include ASXL1, ASXL2, HCF1, OGT, and the forkhead transcription factors FOXK1 and FOXK2 [9], and BAP1 can deubiquitinate and stabilize OGT [26]."
39984455
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"XREF_BIBR, XREF_BIBR, XREF_BIBR BAP1 also deubiquitylates OGT and regulates its levels."
23867514
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"BAP1 deubiquitinates and stabilizes OGT [75], while CDK1 phosphorylates KIF18A during mitosis at S674/S684."
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