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TNFAIP3 inhibits signal transduction. 9 / 9
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"More importantly, tnfaip3 and tnip1 genes play key roles to regulate NF-κB signaling in psoriasis, and Ebosin can increase the expression of A20, a key player in the negative feedback regulation of NF-kappaB signaling encoded by tnfaip3, which has been reported to attenuate NF-κB signaling pathway by editing the ubiquitination of proximal signaling proteins including TRAF6, MALT1, RIPK1, NEMO, UBCH5C, etc (44)."
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"In more than half of ABC DLBCL cases, deletions or inactivating mutations in the TNFAIP3 (A20) tumor suppressor gene and genetic defects in some other protooncogenes and tumor suppressor genes that regulate the NF-κB signaling pathway were found to have activated this signaling pathway irregularly (Compagno et al., 2009)."
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"Hence, A20 is known as tumor necrosis factor α-induced protein 3 (TNFAIP3) (11), which negatively regulates the NF-κB signaling pathway (12)."
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"The TNFR1 associated inhibitor A20 has been reported to induce RIP poly-ubiquitination and inhibit TRADD downstream signal transduction in T cells ( xref , xref )."
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"We found that TNFAIP3 inhibited the TNF signaling pathway, which could inhibit cell migration and proliferation and contribute to apoptosis."
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"In summary, our study reported a HA20 patient with de novo missense variant of TNFAIP3 that inhibited A20 expression and activated NF-κB signaling pathway."
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"Tnfaip3 is a potent inhibitor of the NF-κB signaling pathway and effectively suppresses its activation [37]."
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"Primarily, TNFAIP3 impedes the activation of the P38MAPK signaling pathway within Leydig cells, thus preventing apoptosis."
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"20 , 38 , 39 , 40 For example, TNFAIP3 can negatively regulate the NF‐κB signaling pathway through cooperation of the OTU and ZnF4 domains."
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