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Iron atom activates KCNMA1. 3 / 3
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"In comparison with DHLA, the well-known lipoxygenase inhibitor nordihydroguaiaretic acid and the nonspecific iron reductant sodium dithionite inhibited SLO dependent linoleic acid peroxidation with an IC (50) of 4 and 100 microM, respectively, while the hydrophilic thiol N-acetylcysteine, albeit possessing iron reducing and radical scavenging properties, was ineffective."
14607519
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"Soluble guanylyl cyclase (sGC) contains an iron (heme) center that serves to bind NO, however, this site is also targeted by CO, which can activate sGC, leading to increased cytosolic [cGMP], PKG activation and enhanced BK channel activity."
25202279
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"Addition of ferrous iron and/or cupric copper induced some salivary lipid oxidation (SLO) in all artificial saliva solutions, with the exception of the artificial saliva (AS) solution that contained no organic components (AS1); this solution showed very little metal-induced LO (Figure 1)."
36554714