IndraLab

Statements

USP1 is phosphorylated. 21 / 21
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"Identification of USP1 phosphorylation sites by mass spectrometry."
23116119
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"Further experiments showed that USP1 phosphorylation is essential for interaction with UAF1 and its protease activity ( xref )."
29362236
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"Moreover, 20E induced USP1 and CDK10 phosphorylation."
25728569
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"By contrast, lambda protein phosphatase (λPPase) treatment degraded USP1 and CDK10 phosphorylation."
25728569
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"Recent work showed that phosphorylation of USP1 by kinase CDK1 promotes the complex formation between USP1 and UAF1( xref )."
23797609
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"Mutation analysis of the phosphorylated USP1 residues."
23116119
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"Our observation revealed a regulatory mechanism of USP1’s activity in which a specific phosphorylation in USP1 and the subsequent interaction with a partner protein UAF1 exert the stimulatory effect on USP1 catalytic activity."
23116119
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"20E via PKC regulates CDK10 xref and USP1 phosphorylation to form the EcR/USP transcription complex xref ."
25728569
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"These results suggest that 20E activates PLCG1 via the ErGPCR and Src family kinases to regulate Ca(2+) influx and PKC phosphorylation of USP1 to subsequently modulate gene transcription for metamorphosis."
24692553
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"Phosphorylation of USP1 has been shown as a key regulator in its interaction with the protein partner USP1-associated factor 1 (UAF1)( xref )."
23797609
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"For example, the CDK1mediated serine phosphorylation of USP1 disrupts the interaction between USP1 and UAF1."
35627217
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"Increased levels of 20E antagonizes phosphorylation of Akt and instead promotes 20E-responsive gene transcription indirectly by promoting phosphorylation of USP1, which enhances EcR-B1/USP1 binding to ecdysone response elements."
31955616
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"USP1 phosphorylation via cyclin-dependent kinases (Cdks) might have a role in prevention of premature degradation of USP1 during cell cycle progression [ xref ]."
28659380
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"In contrast, two other known USP1 serine phosphorylations (Ser42 and Ser67) are dispensable with respect to the activity of the USP1/UAF1 complex."
23116119
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"20E, via GPCRs, induces rapid increase in cellular calcium and phosphorylation of transcription complex proteins USP1 and CDK10 to activate gene transcription xref ."
25728569
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"The non-phosphorylated HaCal then binds with the non-phosphorylated USP1, which might promote the interaction between USP1 and other proteins such as Met1 in the JH signaling cascade ( xref )."
21625546
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"These results suggest that Gαq participates in 20E signaling in the cell membrane at the pre-genomic stage by modulating the increase of the intracellular Ca(2+) and phosphorylation of CDK10 and USP1 in 20E transcription complex to regulate gene transcription."
25125388
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"After phosphorylation of USP1, the complex translocated to the nucleus, where the recruitment of the Fanconi anemia protein FANCD2 and PCNA substrates mediated by a SUMO-like domain occurs in response to DNA damage ( xref ; xref ; xref ; xref )."
34177595
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"ErGPCR-2 knockdown repressed 20E-induced USP1 and CDK10 phosphorylation ( xref ), which are essential for the formation of EcRB1/USP1 transcription complex to initiate gene transcription in 20E signaling xref xref ."
25728569
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"Specifically, we demonstrate that USP1 is phosphorylated in mitosis by cyclin-dependent kinases (Cdks), and that this phosphorylation event may prevent premature degradation of USP1 during normal cell cycle progression."
22101265
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"20E via GPCR-, PLC-, Ca 2+ -, and PKC-signaling mediates USP1 phosphorylation for gene transcription xref ."
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