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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TP53 hydroxylated on K382 decreases the amount of TP53. 1 / 1

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"It is postulated that this hydroxylation on K382 of p53 negatively regulates the p53 pathway by antagonizing the acetylation (enhancer of p53 transcription) of this site, thereby promoting the interaction of p53 with its negative regulator double minute X human homolog (MDMX) and downregulating transcriptional activity of p53."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...