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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

CDK4 phosphorylates RB1 on serine. 2 / 2

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"CDK4 and CDK6 specific phosphorylation of Rb on serine 807-811 (pSRb) confirmed that the CDK4 and cyclin D1 holoenzyme was active in MCL cells, along with CDK6 and cyclin D1 in MCL7 and CDK4 and cyclin D2 in MCL6."

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"PD 0332991 completely inhibited CDK4 and CDK6 within 24 hours, as indicated by the loss of CDK4 and CDK6 specific phosphorylation of Rb on serine 807-811 (pRb), arrested the cell cycle in G1, and marked reduction of DNA replication as measured by BrdU pulse labeling (XREF_FIG)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...