IndraLab

Statements

CDK4 phosphorylates RB1 on serine. 6 / 6
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reach
"Cdk4 phosphorylates pRB at specific serine residues, Ser780, Ser795 and Ser807/811, when cells progress from G 0 /G 1 to G 1 /S phases of the cell cycle."
16750360
reach
"PD 0332991 completely inhibited CDK4 and CDK6 within 24 hours, as indicated by the loss of CDK4 and CDK6 specific phosphorylation of Rb on serine 807-811 (pRb), arrested the cell cycle in G1, and marked reduction of DNA replication as measured by BrdU pulse labeling (XREF_FIG)."
25744718
reach
"Biomarker analyses of (a) Rb, (b) phosphorylated Rb (assessing CDK4 and CDK6 specific phosphorylation of Rb on serine 807-811), and (c) Ki-67 of patients in the phase 1 study."
25813205
reach
"As Rb phosphorylation by CDK4 and CDK6 occurs specifically on serine residuesExpert Opin."
24369047
sparser
"Cdk4 phosphorylates pRB at specific serine residues, Ser780, Ser795 and Ser807/811, when cells progress from G 0 /G 1 to G 1 /S phases of the cell cycle."
16750360
reach
"CDK4 and CDK6 specific phosphorylation of Rb on serine 807-811 (pSRb) confirmed that the CDK4 and cyclin D1 holoenzyme was active in MCL cells, along with CDK6 and cyclin D1 in MCL7 and CDK4 and cyclin D2 in MCL6."
23676220