IndraLab

Statements

MIR454 activates USP47. 2 / 2
| 2
eidos
"KCNQ1OT1 confers DDP resistance in NPC cells via upregulating USP47 expression by sponging miR-454 Subsequently , the RT-qPCR results demonstrated that miR-454 and USP47 expression levels were significantly decreased in 5-8F / DDP and SUNE-1 / DDP cells following transfection with miR-454 inhibitor or shUSP47 compared with the NC inhibitor and shNC groups , respectively , which suggested that miR-454 inhibitor and shUSP47 downregulated miR-454 and USP47 expression levels in DDP-resistant NPC cells , respectively ( Fig. 6A and B ) ."
33576460
eidos
"Compared with the shNC group , KCNQ1OT1 knockdown significantly downregulated USP47 expression , and miR-454 knockdown significantly reversed shKCNQ1OT1-mediated effects on USP47 expression ."
33576460