IndraLab

Statements

SNAI2 binds TP53 and MDM2. 9 / 9
| 4 5
reach
"The study suggested that wt p53 can bind to MDM2 and Slug simultaneously to form a p53, MDM2, and Slug complex, which then facilitates MDM2 mediated degradation of Slug [XREF_BIBR]."
29783720
sparser
"Slug interactions with the p53 protein are believed to be mediated via Mdm2, with formation of a wild type p53-Mdm2-Slug complex leading to degradation of Slug ( xref )."
24008423
sparser
"In addition, wild type p53 upregulates MDM2 and forms a p53-MDM2-Slug complex to degrade Slug in non-small-cell lung cancer cells, and Slug expression level correlates positively with lung adenocarcinoma metastasis in HCC patients xref ."
24023784
reach
"In addition, wild type p53 upregulates MDM2 and forms a p53, MDM2, and Slug complex to degrade Slug in non-small-cell lung cancer cells, and Slug expression level correlates positively with lung adenocarcinoma metastasis in HCC patients XREF_BIBR."
24023784
sparser
"The study suggested that wt p53 can bind to MDM2 and Slug simultaneously to form a p53-MDM2-Slug complex, which then facilitates MDM2-mediated degradation of Slug [ xref ]."
29783720
sparser
"Recent reports have indicated that p53 also controls Slug levels, binding it together with Mdm2 to form the Mdm2-p53-Slug complex, which facilitates the Mdm2-induced degradation of Slug [25] ."
23438693
sparser
"SLUG is known as an invasion promoter by repressing E-cadherin transcription, and p53 contributes to maintaining E-cadherin by enhancing the degradation of SLUG by forming MDM2-p53-SLUG complex [ xref ]."
| PMC
reach
"This was shown to occur through a p53, Mdm2, and Slug complex; interestingly, mutant and transcriptionally-inactive p53 inactivates the Mdm2 mediated degradation of Slug [XREF_BIBR]."
25201198
reach
"Recent reports have indicated that p53 also controls Slug levels, binding it together with Mdm2 to form the Mdm2, p53, and Slug complex, which facilitates the Mdm2 induced degradation of Slug [25]."
23438693