IndraLab

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TP53 binds MDM2 and SNAI2. 13 / 13
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"This was shown to occur through a p53, Mdm2, and Slug complex; interestingly, mutant and transcriptionally-inactive p53 inactivates the Mdm2 mediated degradation of Slug [XREF_BIBR]."
25201198
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"Slug interactions with the p53 protein are believed to be mediated via Mdm2, with formation of a wild type p53-Mdm2-Slug complex leading to degradation of Slug ( xref )."
24008423
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"Recent reports have indicated that p53 also controls Slug levels, binding it together with Mdm2 to form the Mdm2-p53-Slug complex, which facilitates the Mdm2-induced degradation of Slug [25] ."
23438693
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"The study suggested that wt p53 can bind to MDM2 and Slug simultaneously to form a p53-MDM2-Slug complex, which then facilitates MDM2-mediated degradation of Slug [ xref ]."
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"In addition, wild type p53 upregulates MDM2 and forms a p53, MDM2, and Slug complex to degrade Slug in non-small-cell lung cancer cells, and Slug expression level correlates positively with lung adenocarcinoma metastasis in HCC patients XREF_BIBR."
24023784
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"In addition, wild type p53 upregulates MDM2 and forms a p53-MDM2-Slug complex to degrade Slug in non-small-cell lung cancer cells, and Slug expression level correlates positively with lung adenocarcinoma metastasis in HCC patients xref ."
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"The study suggested that wt p53 can bind to MDM2 and Slug simultaneously to form a p53, MDM2, and Slug complex, which then facilitates MDM2 mediated degradation of Slug [XREF_BIBR]."
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"Notably, p53, a key molecule tumor suppressor in the p53 signaling pathway, was in turn confirmed to interact with MDM2 to form the p53-MDM2-Slug complex, which promotes MDM2-mediated Slug degradation and ultimately inhibits cancer invasion and metastasis [32]."
40109856
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"SLUG is known as an invasion promoter by repressing E-cadherin transcription, and p53 contributes to maintaining E-cadherin by enhancing the degradation of SLUG by forming MDM2-p53-SLUG complex [ xref ]."
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"TP53 can facilitate degradation of SNAIL2 through the p53-SNAIL2-MDM2 complex ( Lim et al., 2010 )."
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"Recent reports have indicated that p53 also controls Slug levels, binding it together with Mdm2 to form the Mdm2, p53, and Slug complex, which facilitates the Mdm2 induced degradation of Slug [25]."
23438693
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"In the absence of p53, instead of forming the p53-Mdm2-Slug complex that ensures the degradation of Slug, Mdm2 can stabilize mRNA of Slug via its RING domain, thus contributing to the accumulation of this protein."
35813818
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"To maintain the normal function of the P53 pathway is mediated by MDM2, which in turn, these two molecules bind to the Slug and forms the P53-MDM2-slug complex."
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