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CYLD inhibits ERK. 21 / 26
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"CYLD also enhances oxidative stress by inhibiting the activation of the extracellular signal regulated kinase (ERK), p38/AP -1 and c-Myc pathways, ensuring Nrf2 downregulation."
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"However, it remains unknown if CYLD also suppresses ERK activation induced by bacterial pathogens."
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"As shown in XREF_FIG, CYLD WT inhibited ERK phosphorylation, while CYLD knockdown, via siCYLD, markedly enhanced ERK activation by NTHi (XREF_FIG)."
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"Interestingly, CYLD suppresses NTHi induced ERK activation by upregulating another negative regulator, MAP Kinase Phosphatase-1 (MKP-1)."
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"Thus, it is possible that ERK or its upstream molecules including MEK1/2, Raf and MEKK1 (64, 65) may be polyubiquitinated via K63, and CYLD may inhibit the activation of ERK by deubiquitinating ERK or its upstream molecules."
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"Consistent with the results shown in Fig. 2, the phosphorylation of two key kinases (Akt and ERK) caused by CYLD knockdown was significantly suppressed by gefitinib treatment alone (Fig. 3F)."
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"In addition, it is also possible that CYLD may inhibit ERK activation and inflammation via up-regulation of MAPK phosphatase-1 (MKP-1)."
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"CYLD inhibits NTHi induced activation of ERK."
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"We thus asked whether CYLD inhibited ERK activation."
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"Taken together, the CYLD suppression of ERK dependent IL-8 via MKP-1 may bring novel insights into the tight regulation of inflammatory responses and also lead to innovative therapeutic strategies for controlling these responses by targeting key negative regulators of inflammation."
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"Next, we further verified that Cyld inhibited B cell proliferation and augmented B cell apoptosis in miR-130b overexpressed mice.The downstream of BCR signaling consists of NFAT, NF-κB and ERK pathway[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Collectively, it is evident that CYLD specifically inhibits the activation of ERK induced by bacterial pathogen in both human and mouse cells."
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"Consistent with this, CYLD negatively regulates Haemophilus influenzae -induced IL-8 production via inhibition of ERK [ 43 ]."
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"We next sought to determine how CYLD negatively regulates the ERK signaling pathway in order to mediate NTHi induced IL-8 expression."
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"These studies provide insights into the molecular mechanisms underlying the tight regulation of inflammation via inhibition of ERK by CYLD and identified vinpocetine as a potential therapeutic agent for suppressing the inflammatory response in the pathogenesis of OM via upregulating negative regulator CYLD expression."
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"Vinpocetine inhibited S. pneumoniae -induced inflammatory response via inhibition of mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase (ERK) by CYLD."
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"Here we provide clear evidence that CYLD inhibits NTHi induced activation of ERK (XREF_FIG), and we also demonstrate that CYLD controls IL-8 expression via specifically targeting ERK phosphorylation by activating the ERK pathway with a constitutively active form of MEK (XREF_FIG)."
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"These studies provide insights into the molecular mechanisms underlying the tight regulation of inflammation via inhibition of ERK by CYLD and identified vinpocetine as a potential therapeutic agent for suppressing the inflammatory response in the pathogenesis of OM via upregulating negative regulator CYLD expression."
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"Future studies will focus on using DUB activity deficient CYLD mutant constructs to determine whether DUB activity is essential for the CYLD mediated suppression of ERK signaling pathway induced by bacterial pathogens."
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"In addition, we further investigated the detailed mechanism by which CYLD negatively regulates the ERK signaling pathway in a DUB activity dependent or independent manner."
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"CYLD Impairs Production of Cytokines, ROS, and NO and Reduces Activation of NF-kappaB, ERK1/2, and p38MAPK in Lm Infected BMDM."
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