IndraLab

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PRMT5 methylates TP53 on arginine. 14 / 14
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"Arginine methylation of E2F1 and p53 by PRMT5 reportedly influences protein stability; therefore PRMT5 regulates cell cycle progression and cell death [14,22,23]."
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"In 2008, Jansson et al demonstrated that PRMT5 can methylate p53 at arginine residues 333, 335 and 337 to activate transcription of p21 and promote G 1 cell cycle arrest in response to DNA damaging agent etoposide ( xref )."
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"6 A physical interaction of TTC5 with Protein Methyltransferase 5 (PRMT5), which arginine methylates TP53, has been reported, 7 as has a regulatory role for TTC5 in steroid hormone signaling where it acts as a cofactor for the glucocorticoid and estrogen receptors."
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"In conclusion, the present study, using an innovative in vivo model integrating the stress responsive Gadd45beta-luciferase transgene and inducible oncogenes (LSL-K-ras G12D and Myc ER), uncovers two novel and significant findings : (i) normal HSPCs utilize arginine methylation of p53 by PRMT5 to orchestrate long lasting oncogenic response."
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"In Fanca-/- and Fancc -/- mice, arginine methylation of p53 by PRMT5 was decreased in response to oncogenic stress [XREF_BIBR]."
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"The authors showed that PRMT5 methylates p53 at selected arginine residues in p53 oligomerization domain."
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"Thus, these studies defined a compromised oncogene induced arginine methylation of p53 by PRMT5 as one mechanism for the short lived oncogenic stress response in FA HSPCs."
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"Because PRMT5 has been shown to mediate arginine methylation of p53 to regulate its function [XREF_BIBR, XREF_BIBR], we explored the effects of AMI-1 on p53 in nude mouse CRC xenograft model."
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"Jansson et al. demonstrate that arginine methylation of p53 by PRMT5 regulates target gene specificity of p53 by altering promoter binding."
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"A second centers on how arginine methylation of histones, E2F1 and p53 (as well as yet to be identified substrates) by PRMT5 is coordinated for neoplastic growth."
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"PRMT5 induces arginine methylation of tumor suppressor p53 on the arginine 333,335 and 337 and affects the p53 target gene specificity, thereby escaping p53 surveillance and leading to tumorigenesis."
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"In addition, by stimulating PRMT5/MEP50-dependent arginine-methylation of p53, cyclin D-CDK4/6 suppresses the expression of key anti-proliferative and pro-apoptotic p53-target genes (40)."
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"Mechanistic studies reveal that FA deficiency in HSPCs impairs oncogenic stress induced G 1 cell-cycle checkpoint, resulting from a compromised K-ras G12D -induced arginine methylation of p53 mediated by the protein arginine methyltransferase 5 (PRMT5)."
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"Apart from epigenetic modifications, PRMT5 has been shown to mediate arginine methylation of P53 to regulate its function."
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