IndraLab

Statements

USP3 inhibits Ubiquitin. 5 / 6
| 1 4
reach
"As shown in Fig. 5e, ectopic USP3 expression decreased ubiquitin and K48-linked ubiquitin that combined with DNM1L protein by the proteasome inhibitor MG132, whereas USP3 knockdown impaired DNM1L deubiquitylation."
40197257
trips
"We further identified that the USP3 removes Ub at lysine 13 and 15 of H2A and γH2AX, as well as lysine 118 and 119 of H2AX in response to DNA damage."
24196443
reach
"By virtue of its ability to oppose histone H2A ubiquitylation and the fact that USP3 over-expression can block accumulation of the ubiquitin E3 ligase RNF168 at DSB sites, USP3 has been linked to the key RNF8-RNF168 pathway of assembling repair and signalling components at DSB sites [XREF_BIBR]."
23712866
reach
"The Ub modifications on K119/120 of histone H2A and K13/15 of histone H2B generated by BMI1 and RNF2 and RNF20-RNF40 are attenuated by USP3, an H2A and H2B specific DUB."
28587922
reach
"Sharma et al. revealed that USP3 could eliminate ubiquitin at lysines 13 and 15 of histone H2A and γH2AX, as well as ubiquitin at lysines 118 and 119 of H2AX in response to DNA damage [6]."
38531846