IndraLab

Statements

CYLD decreases the amount of IL4. 4 / 4
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"CYLD-deficient Treg cells furthermore produced high levels of interleukin-4 (IL-4) and failed to suppress allergen-induced lung inflammation."
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"The mRNA level of Il4 was also markedly increased by the CYLD deficiency, whereas that of Ifng, Il17, or Il10 was not changed (Fig 3, B)."
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"Nevertheless, CYLD-deficient Treg cells still produced higher levels of IL-4 even in the presence of WT Treg cells (Fig 3, G) suggesting that CYLD directly restricted production of IL-4 in Treg cells."
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"As our preliminary data shows that CYLD knockdown is able to upregulate IL-4 and Scinderin expression in human Treg cells (data not shown), this indicates that CYLD may play an important role in Treg cells in humans."
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