IndraLab

Statements

CACNA1A activates IK. 10 / 10
| 10
sparser
"Glutamate-stimulation of hippocampal neurons has diverse effects on voltage-dependent activation and inactivation of I K via Ca 2+ /calcineurin-dependent intracellular signaling."
19276663
sparser
"In the present study, we show that in hippocampus, ethanol prevents the NMDA-induced hyperpolarizing shift in the voltage-dependent activation of neuronal I K and reduces the unclustering and dephosphorylation of Kv2.1 channels."
19185209
sparser
"Hyperpolarizing shifts in the voltage-dependent activation of neuronal I K are associated with a dephosphorylation of the Kv2.1 channel ( xref , xref )."
20092568
sparser
"A submaximal concentration of Compound II (50 nM) had a significant effect on the time and voltage dependent activation of iK and caused a positive shift of the iK activation curve."
9550297
sparser
"In agreement with previous studies using exogenously applied glutamate, we observed that bath application of NMDA potently and rapidly unclustered and dephosphorylated Kv2.1 channels and produced a hyperpolarizing shift in the voltage-dependent activation of neuronal I K . Previous studies have shown that hyperactivity associated with seizures or KCl-induced membrane depolarization causes dephosphorylation and unclustering of Kv2.1 channels ( xref )."
18753382
sparser
"Bath application of NMDA potently unclustered and dephosphorylated Kv2.1 and produced a hyperpolarizing shift in voltage-dependent activation of I K . In contrast, driving synaptic activity in Mg 2+ -free media to hyperactivate synaptic NMDA receptors had no effect on Kv2.1 channels, and moderate pentylenetetrazole-induced seizure activity in adult mice did not dephosphorylate hippocampal Kv2.1 channels."
18753382
sparser
"In addition, ischemic conditions produced calcineurin-dependent dephosphorylation and unclustering of Kv2.1, hyperpolarizing shifts in voltage-dependent activation of I K , and reduced spontaneous calcium transients ( xref )."
18753382
sparser
"The voltage-dependent activation of the ATP-induced IK during 500 ms depolarizing test pulses could be described by a Boltzmann equation with a half-activation voltage (V1/2) of 11.5 mV and slope factor (k) of 12.0 mV, which were close to those of IKs (V1/2 of 12.1 mV and k of 12.3 mV), determined as an E-4031-resistant IK, under the same isochronal (500 ms) activation conditions."
9288673
sparser
"As expected, bath application of NMDA to hippocampal cultures reduced the size of Kv2.1 clusters and produced a hyperpolarizing shift in the voltage-dependent activation of I K that was associated with dephosphorylated Kv2.1 channels."
19185209
sparser
"Indeed, we found that the cell-permeable Zn 2+ chelator TPEN significantly attenuated the hyperpolarizing shift in the voltage-dependent activation of I K to the same extent as calcineurin inhibition."
20092568