IndraLab

Statements

UCHL1 inhibits Death. 4 / 4
| 4
reach
"In this study we demonstrated that the inhibition of Uch-L1 induces BACE1 up-regulation and increases neuronal cell death in control as well as in AD transgenic mouse models subjected to Bengal Rose, a light sensitive dye inducing a cortical infarction through photo activation."
29033830
reach
"Together, these studies indicate that UCH-L1 inhibition induced by genetic mutations or pathological conditions is an important contributor not only to the accumulation of ubiquitinated proteins in ag[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15194490
reach
"Deletion of UCHL1 produces progressive neurodegeneration, sensory and motor ataxia, and premature death in mice (Chen et al., 2010; Coulombe et al., 2014; Reinicke et al., 2019; Saigoh et al., 1999; Walters et al., 2008; Yamazaki et al., 1988)."
33159930
reach
"UCH-L1 prevents neuronal cell death from oxidative stress, and down-regulation of UCH-L1 leads to neuronal degeneration [XREF_BIBR, XREF_BIBR]."
24998396