IndraLab

Statements

UCHL1 inhibits Death. 8 / 8
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"Loss of UCHL1 function leads to attenuation of both the ubiquitin‒proteasome pathway and autophagy-lysosomal pathway, facilitating cellular damage and death [43]."
39695855
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"UCHL1 may insure ubiquitin stability within neurons ( Osaka et al., 2003 ) thus possibly preventing neuronal death and neurodegenerative diseases."
22285475
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"UCH-L1 prevents neuronal cell death from oxidative stress, and down-regulation of UCH-L1 leads to neuronal degeneration [XREF_BIBR, XREF_BIBR]."
24998396
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"Together, these studies indicate that UCH-L1 inhibition induced by genetic mutations or pathological conditions is an important contributor not only to the accumulation of ubiquitinated proteins in ag[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15194490
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"The result indicated that dUCH deficiency may lead to the death/degeneration of IPCs."
35985499
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"Collectively, the present results revealed that under the normal diet, the knockdown of dUCH might induce oxidative stress and mitochondrial fusion, and consequently cause IPCs death/degeneration and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35985499
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"Deletion of UCHL1 produces progressive neurodegeneration, sensory and motor ataxia, and premature death in mice (Chen et al., 2010; Coulombe et al., 2014; Reinicke et al., 2019; Saigoh et al., 1999; Walters et al., 2008; Yamazaki et al., 1988)."
33159930
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"In this study we demonstrated that the inhibition of Uch-L1 induces BACE1 up-regulation and increases neuronal cell death in control as well as in AD transgenic mouse models subjected to Bengal Rose, a light sensitive dye inducing a cortical infarction through photo activation."
29033830