IndraLab

Statements

Cyclin phosphorylates NPM1 on T199. 4 / 5
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"T199 phosphorylation of NPM1 is mediated by the cyclin dependent kinases CDK1 and CDK2, which in turn play a key role in NPM1 dissociation from nucleolar components."
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"NPM1 is phosphorylated at Threonine 199 by the cyclin dependent kinases CDK1 and CDK2 during the cell cycle [XREF_BIBR]."
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"Viral cyclin (vCyclin), a homolog of cellular cyclin D2, phosphorylates threonine 199 of nucleophosmin (NPM), a histone chaperone that plays roles in transcriptional control and chromatin organization."
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"Here we have shown that NPM, which controls the process of centrosome replication, is phosphorylated on T199 by D1/K2 and Cyclin E/Cdk2 complexes, but not by Cyclin D1/Cdk1 or Cyclin D1/Cdk4."
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