IndraLab

Statements

MTOR decreases the amount of IRS1. 10 / 10
| 10
reach
"It also has been reported that mTOR inhibition will enhance insulin receptor substrate-1 expression and abrogate feedback inhibition of the pathway, resulting in Akt activation both in cancer cell lines and in patient tumors [XREF_BIBR]."
22559167
reach
"The mTOR active site inhibitor, Torin1, which inhibits mTORC1 and mTORC2, increased IRS-1 levels both during acute and prolonged treatment (XREF_FIG)."
23142081
reach
"In particular, mTOR inhibition induced insulin receptor substrate 1 (IRS-1) expression and abrogated feedback inhibition of the pathway, leading to Akt activation in cancer cell lines and in primary cell cultures [11]."
32748870
reach
"Loss-of-function and pharmacological inhibition studies have shown that the mTOR target S6K1, for instance, inhibits and desensitizes insulin-PI3K signaling by phosphorylating IRS1 protein and suppressing IRS1 gene transcription."
21962509
reach
"While pre-clinical study demonstrates that prolonged rapamycin treatment suppresses Akt and PKB signaling due to the destabilization of mTORC2 in some types of cultured cancer cells, 172 the results from recent clinical trials provide evidence about PI3K-Akt activation in patient tumors treated with rapamycin or the rapamycin analog RAD001, XREF_BIBR, XREF_BIBR Thus, Dr. Rosen 's group demonstrated that mTOR inhibition with RAD001 treatment induced IRS-1 expression and Akt activation in patient tumors."
19177005
reach
"49 Despite promising clinical results, inhibition of mTOR results in induction of insulin receptor substrate-1 expression, causing a paradoxical Akt activation both in cancer cell lines and in patient tumors treated with mTOR inhibitors."
23604238
reach
"XREF_BIBR The inhibition of mTOR could induce insulin receptor substrate-1 expression to activate AKT."
31571914
reach
"MTOR pathway inhibitors like rapamycin activates such siganling by inducing the expression of insulin receptor substrate-1 (IRS-I), resulting in Akt activation XREF_BIBR."
27680387
reach
"Therefore, mTOR inhibition will increase IRS-1 protein expression, resulting in Akt activation XREF_BIBR."
22059905
reach
"We now show that mTOR inhibition induces insulin receptor substrate-1 expression and abrogates feedback inhibition of the pathway, resulting in Akt activation both in cancer cell lines and in patient tumors treated with the rapamycin derivative, RAD001."
16452206