Other Services

This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Modified MIR7-1 decreases the amount of IRS1. 2 / 2

| 2

➶

reach

"Further studies showed that over-expression of miR-7 down-regulated insulin receptor substrate 1 (IRS1) expression as well as inhibited insulin stimulated Akt phosphorylation and glucose uptake."

21183973

➶

reach

"Similarly, in another cellular IR model (C2C12 myoblasts pretreated with fatty acids), overexpression of miR-7 downregulates IRS-1 expression via a direct interaction through binding to its 3 '-UTR [XREF_BIBR]."

27763497

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...