IndraLab

Statements

USP30 increases the amount of reactive oxygen species. 2 / 2
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"In this regard, we further observed that co-depletion of STK38 and USP30 was sufficient to fully restore total mitochondrial mass and mitochondrial ROS levels to normal values as observed in control cells."
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"Even more importantly, depletion of USP30, a major opponent of PINK1 and Parkin mediated mitophagy [XREF_BIBR, XREF_BIBR], partially restored soft agar growth, and fully restored total mitochondrial mass and ROS levels of STK38 depleted Ras transformed cells."
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