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USP18 activates CXCL10. 3 / 3
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"In this study, overexpression of USP18 further raised the levels of inflammatory factors, and promoted the synthesis and secretion of IFN-β and chemokine CXCL10 in IAV-infected A549 cells."
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"STAT1 , USP18 and IRF1 modulate CXCL10 levels in EC following IFN-alpha stimulation To validate the transcriptional regulations inferred in our multiple-output FFL regulatory subnetwork ( Fig. 2 ) , we measured CXCL10 protein levels in tissue culture media conditioned by STAT1 - , USP18 - , IFIH1 - and IRF1-silenced HUVECs , compared to HUVECs transfected with a scrambled siRNA ( siCTRL ) ."
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"What’s more, overexpression of USP18 further enhanced the synthesis and secretion of IL-6, TNF-α, IFN-β and CXCL10 after PR8 infection ( Fig. 2 A and B), while inhibition of USP18 had an opposite effe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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