IndraLab

Statements

CYLD inhibits IL18. 4 / 4
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reach
"CYLD, another USP, restricts IBD inflammation in the colonic mucosa by inhibiting excessive production of IL-18 through deubiquitinating NLRP6 (70)."
38322269
reach
"As expected, the mRNA expression levels of NF-κB down-streaming signals including Bcl-2, Mcl-1, MMP-9, Snail, NFKBIA, IL-1β, IL-6 and IL-18 were almost restored by CYLD knockdown in T24 and SW780 cell[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36538852
eidos
"For the regulation of the NLRP6 inflammasome , Mukherjee et al. [ 107 ] found that the assembly of this inflammasome was regulated by deubiquitinase Cyld , which mediates deubiquitination of NLRP6 ; as a consequence , Cyld inhibits NLRP6-ASC assembly and IL-18 production ."
33808793
eidos
"Further , the abundance of IL-18 in the colonic mucosa negatively correlates with CYLD expression in patients with IBD , suggesting that reduced CYLD expression results in elevated IL-18 and contributes to the pathogenesis of IBDs ."
32424362