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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

CYLD inhibits IL18. 2 / 2

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"Further , the abundance of IL-18 in the colonic mucosa negatively correlates with CYLD expression in patients with IBD , suggesting that reduced CYLD expression results in elevated IL-18 and contributes to the pathogenesis of IBDs ."

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"For the regulation of the NLRP6 inflammasome , Mukherjee et al. [ 107 ] found that the assembly of this inflammasome was regulated by deubiquitinase Cyld , which mediates deubiquitination of NLRP6 ; as a consequence , Cyld inhibits NLRP6-ASC assembly and IL-18 production ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...