IndraLab

Statements

CYLD inhibits IL18. 2 / 2
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eidos
"Further , the abundance of IL-18 in the colonic mucosa negatively correlates with CYLD expression in patients with IBD , suggesting that reduced CYLD expression results in elevated IL-18 and contributes to the pathogenesis of IBDs ."
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eidos
"For the regulation of the NLRP6 inflammasome , Mukherjee et al. [ 107 ] found that the assembly of this inflammasome was regulated by deubiquitinase Cyld , which mediates deubiquitination of NLRP6 ; as a consequence , Cyld inhibits NLRP6-ASC assembly and IL-18 production ."
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