IndraLab
Statements
reach
"While transfection with empty vector and subsequent forskolin treatment again showed significant downregulation of p53 protein, p53 overexpression completely abrogated forskolin induced downregulation of p53 and showed no significant difference in p53 protein levels between forskolin stimulation and vehicle control."
reach
"13 These phenotypes seen in HPV16E6 expressing human cells have been reproduced using other means to inactivate p53 including expression of dominant negative p53 alleles and RNAi mediated depletion of p53 protein expression, XREF_BIBR - XREF_BIBR demonstrating that the phenotypes are likely derived from the effects of HPV16E6 on p53."
reach
"Expression of exogenous Plk1 and p53 in p53 deficient lung carcinoma H1299 cells greatly decreased the p53 mediated transcription from the p53 responsive p21 (WAF1), MDM2, and BAX promoters, whereas the kinase deficient mutant form of Plk1 failed to reduce the transcriptional activity of p53."
reach
"Similarly, Kuenzi et al., have reported increased p53-ser15 phosphorylation but decreased expression of p53 in fungal alkaloid, militarinone A treated N2a cells XREF_BIBR, indicating the activation of p53 by increased phosphorylation at ser15 might reduce p53 level in curcumin treated N2a cells."
reach
"Expression of exogenous Plk1 and p53 in lung carcinoma H1299 cells deficient in p53 greatly decreased the p53 mediated transcription of the p53 responsive p21, MDM2, and BAX promoters, whereas the kinase deficient mutant Plk1 failed to reduce the transcriptional activity of p53 [XREF_BIBR], suggesting that Plk1 mediated negative regulation of p53 might be a fundamental mechanism for the role of Plk1 in oncogenesis."